Whitney Palmer

Healthcare. Politics. Family.

Low Protein and Osteoporosis in Men?

Published on the Sept. 21, 2016, Rheumatology Network website

By Whitney L. Jackson

Low protein intake may be responsible for fractures in older men, according to an observational study that analyzed data from the 2000-2002 Osteoporotic Fractures in Men Study.

Dietary protein is a potentially modifiable risk factor for controlling fractures among older men.

In a Sept. 18 presentation at the American Society of Bone Mineral Research annual conference in Atlanta, lead study author Lisa Langsetmo, M.D., from the University of Minnesota, discussed the investigators’ hypothesis that lower-to-moderate protein intake was associated with an increased fracture risk while high protein intake was not.

“Increased dietary protein intake may be feasible as a low-risk intervention to reduce the risk of hip fracture among older men,” she said.

The study, which included 5,875 men — average age 73.6 years — had two objectives: to assess the association of protein intake with low trauma (trauma < fall from standing height) fracture risk and to assess whether the association between protein intake and fracture risk was mediated by falls, body mass index, bone mineral density, appendicular lean mass or gait speed.

Researchers took baseline protein assessment and excluded men with < 500 kcal/d total energy intake or missing ­­> 10 items. The median was 15.9 percent total energy intake with a range from 14.2 percent to 17.8 percent. They defined low protein intake as the bottom quartile and high intake at the top quartile, Dr. Langsetmo said.

According to the analysis, there were 808 low trauma fractures, excluding head, hands, and feet, over 15 years. Results showed a 16-percent lower hip fracture risk, and an 8-percent lower major osteoporotic fracture risk.

Low protein intake was associated with increased fracture risk (HR=1.28, 95 percent CI, 1.08-1.51) compared to those with moderate intake. High protein intake was not associated (HR=1.00, 95 percent CI, 0.84-1.19). There was a two point change in estimates when they were adjusted for falls, body mass index, appendicular lean mass and gait speed.

The protein intake-fracture risk association was dependent on skeletal site, Dr. Langsetmo said. In addition, while the hip fracture association was strong, there was no such association with vertebral fractures.

To read the article at its original location: http://www.rheumatologynetwork.com/news/low-protein-and-osteoporosis-men



September 28, 2016 Posted by | Healthcare | , , , | Leave a comment

Growth of Interventional Radiology

Published on the Sept. 22, 2016, DiagnosticImaging.com website

By Whitney L. Jackson

Historically, mention of interventional radiology conjured up thoughts of vascular techniques. Today, this area of radiology encompasses much more – in fact, according to industry experts, it’s growing quickly and is expanding heavily throughout health care as a whole.

But, what’s behind this extension, and how has it – and will it – affect diagnostic radiology?

These changes, said Matt Hawkins, MD, director of pediatric interventional radiology (IR) at Emory University School of Medicine, will likely change the health care landscape in the years to come.

“Interventional radiology will play a bigger role moving forward,” he said. “As we measure the overall cost and value, we can do a lot in interventional radiology that costs less and positively impacts patients.”

Interventional Radiology’s Changing Face
For many years, IR was used mainly to make cardiovascular procedures less invasive, but in recent years, these techniques have been applied to other specialty areas, as well, according to the Advisory Board. In addition to medical oncology and pediatrics, IR is gaining ground in neurology, gastroenterology, and urology.

A Transparency Market Research report indicated the most common IR procedures include angioplasty, venous access, biopsy, fibroid embolization, stents, arteriograms, and embolization.

Providers are using IR more frequently in these ways because the techniques are more cost effective, less disruptive to the body, and can be done in the outpatient setting. Based on the Advisory Board analysis, increased use of IR in research is strengthening the quantitative data to support IR’s value in radiology as a whole.

To read the remainder of the article at its original location: http://www.diagnosticimaging.com/interventional-radiology/growth-interventional-radiology

September 23, 2016 Posted by | Healthcare | , , , | Leave a comment

Fracture Assessment Tools Underutilized, Study Shows

Published on the Sept. 19, 2016, RheumatologyNetwork.com Website

By Whitney L. Jackson

Using the fracture assessment tool with older, community-dwelling women can help reduce their risk of hip fracture over time, according to a randomized controlled trial.

Currently, although the cost of fractures is high for both society and individuals, the use of fracture risk tools to identify at-risk patients — and potentially stave off future fractures — is relatively low. The FRAX assessment tool identifies high-risk individuals in primary care environments in an effort to reduce fracture incidence.

The FRAX study was developed by the World Health Organization to evaluate fracture risk based on individual patient models that integrate risk associated with clinical risk factors, as well as bone mineral density at the femoral neck. The FRAX algorithms provide a 10-year fracture probability.

In fact, according to a 2010 study, the National Osteoporosis Foundation Guide recommends treating patients who have a FRAX 10-year score of ≥3 percent for hip fractures or ≥ 20 percent for major osteoporotic fractures to reduce future fracture risks.

In a Sept. 19, presentation at the 2016 American Society of Bone Mineral Research conference, lead author E.V. McCloskey, M.D., from the University of Sheffield in the United Kingdom, discussed a five-year, two-arm study into the efficacy of using the FRAX tool to pinpoint women with osteoporosis who are also at high fracture risk in the community.

Of the 12,483 women identified in primary care environments, 6,233 were randomized into the study’s screening arm. In that group, 898 women (14.4 percent) were identified as high risk using the FRAX tool. By the end of the first year, exposure to osteoporosis medication was higher in the screening group compared to the control group – 15.3 percent versus 4.5 percent, respectively. High treatment uptake occurred in the high-risk group (78.3 percent) at six months.

Results showed the incidence of major osteoporosis fractures – comprising hip, waist, humerus, and clinical vertebral fractures — reduced by 12 percent (2 percent to 21 percent, p=0.018). Screening was associated with a significant reduction in hip fractures (RRR 27 percent, 10 percent – 41 percent, p=0.003).

Based on these findings, researchers wrote, a systematic, community-based screening fracture risk program that uses the FRAX tool in older women can be both feasible and effective in lowering hip fracture risk.

To read the article at its original location: http://www.rheumatologynetwork.com/news/fracture-assessment-tools-underutilized-study-shows

September 20, 2016 Posted by | Healthcare | , , | Leave a comment

Hip Fractures No Longer on a Downward Trend in the U.S.

Published on the Sept. 19, 2016, RheumatologyNetwork.com Website

By Whitney L. Jackson

The 15-year trend of decreasing hip fractures due to osteoporosis is coming to a close in the United States, according to an observational study of Medicare claims data. A drop in reimbursement for a common screening technique could be to blame.

Since 2001, hip fracture rates have dropped thanks to improvements in osteoporosis evaluation and fracture predictions via dual-energy X-Ray absorptiometry (DXA), as well as new drugs, such as oral bisphosphate. DXA uses to X-ray beams to measure bone mineral density and diagnose osteoporosis.

In a Sept. 17, presentation at the 2016 American Society of Bone Mineral Research conference, lead study author E. Michael Lewiecki, M.D., of the New Mexico Clinical Research and Osteoporosis Center, discussed investigators’ analysis of hip fracture rates to determine if the downward trend still existed.

Researchers used Medicare claims and enrollment data from 2002-2014, approximately 900,000 annually, for the analysis. It was five percent sample of Medicare’s fee-for-service beneficiaries who had at least one Medicare-paid DXA scan per year. DXA providers were either office-based, free-standing or hospital-based. Analysts identified hip fractures with ICD-9 codes 820.0x, 820.2x, and 820.8x, excluding trauma-associated fractures.

While the analysis showed a downward trend in osteoporosis-caused hip fractures from 2002-2012, the data revealed a reversal, beginning in 2013. The uptick coincides with a drop in Medicare reimbursement for DXA screening. Reimbursement levels dropped to below cost, Dr. Lewiecki said in an interview with Rheumatology Network.

“The analysis suggests the downward trend for hip fractures in the United States could be over,” he said. “We can’t say that declines in DXA reimbursement are directly responsible for the higher than expected hip fractures, but it makes sense when you look at other contributing factors.”

To combat the drop in screening and, potentially, provide better treatment for osteoporosis, Dr. Lewiecki said patients should educate themselves about the benefits and risk of DXA screening. In addition, he said, patients and providers should support a bill in the U.S. Congress that would create a reimbursement floor for DXA payments that would make providing screening more profitable – or at least less costly – for doctors who have offered the service.

To read the article at its original location: http://www.rheumatologynetwork.com/news/hip-fractures-no-longer-downward-trend-us


September 20, 2016 Posted by | Healthcare | , , , , , | Leave a comment

How One Class of Bisphosphonates Could Predict Vertebral Fractures

Published on the Sept. 19, 2016, RheumatologyNetwork.com Website

By Whitney L. Jackson

Using biomarkers to assess the efficacy of existing bisphosphonate drugs in predicting fracture risk could pave the way for improved osteoporosis treatment, according to a new study.

Currently, little analysis exists into how bisphosphonate drugs can relate bone turnover markers to fracture reduction. With the cost of drug development so high — and with the time to get new drugs approved so long — researchers looked into how available drugs can help reduce fracture risk.

In a Sept. 19 presentation at the America Society of Bone Mineral Research conference, lead study author Douglas Bauer, M.D., from the University of California-San Francisco, discussed how biomarkers, such as blood and urine, can help identify how one class of bisphosphonates can predict vertebral — but not non-vertebral — fractures.

Based on the National Institutes of Health Bone Quality project, investigators analyzed data on more than 120,000 participants from 11 clinical trials, including bone turnover markers, dual-energy X-Ray absorptiometry and fracture outcomes. They recorded baseline data from 2,268 individuals with vertebral fractures, 3,286 with non-spine fractures (including 514 hip fractures), and 6,729 N-telopeptide of type 1 collagen fractures.

Researchers compared the mean effect of the bisphosphonate to the placebo over a three-to-four-year period. Results indicate there’s a high statistically-significant relationship between short-term change and bone markers for vertebral fractures compared to the placebo group (p=0.005, r=0.84). However, no such strong relationship exists for non-vertebral fractures. The findings suggest that non-fragile factors, such as falling, come into play for non-vertebral fractures.

For instance, for two hypothetical bisphosphonates with 10 percent versus 30 percent reductions in bone-specific alkaline phosphatase, the model predicted a 19 percent versus 66 percent reduction in vertebral fractures (r2-0.84, p=0.001). The relationship is weaker and not significant for non-vertebral fractures. The comparable risk reductions were 12 percent versus 21 percent (r2=0.06, p=0.27).

Ultimately, Dr. Bauer told Rheumatology Network, the study results can, hopefully, be useful in developing medications for the same bisphosphonate classes and extending the effects to other populations.

“The hope is that this overall effect can be observed in all anti-absorptive medications that will be developed in the future,” Dr. Bauer said. “Hopefully, all this data will be used to fill in predictive efficacy.”

To read the article at its original location: http://www.rheumatologynetwork.com/news/how-one-class-bisphosphonates-could-predict-vertebral-fractures

September 20, 2016 Posted by | Healthcare | , , , , | Leave a comment

Radiologists in Private Practice

Published on the Sept. 15, 2016, DiagnosticImaging.com website

By Whitney L. Jackson

It’s an iconic image for a young child who wants to be a doctor someday – that sign on a building that announces he or she is available to see patients. For many, being that solo physician is a dream they chase for years.

After finishing residency, not every new radiologist wants to stay close to academia. Many opt to strike out on their own, either launching a solo practice or joining an existing practice of any size. Instead of devoting time and energy to research and teaching the next radiological generation, you’re focused on using your skills to provide the best patient care possible within your community.

According to Stefano Bartoletti, MD, clinical director of radiology at the Children’s Hospital of Pittsburgh, private practice offers practitioners a great amount of leeway, but its safety net is small.

“Private practice allows significant involvement on the part of radiologists managing their own practice and being involved in the decision-making that will shape a group in the future,” he said. “However, this involves some degree of risk taking.”

Given that a private practice option offers less shelter than the umbrella of an academic institution, there are characteristics anyone considering this route should consider.

The ideal of being a doctor in private practice wouldn’t be popular if the career option didn’t offer upsides.

1. Choice of focus: Many private practices do offer some flexibility in how radiologists can choose to focus their time. Even though a significant portion of a provider’s time will be spent reading a myriad of studies from various specialties, it is possible to carve out a niche and grow your business in your chosen subspecialty area within the practice.

2. Face-to-face relationships: Working in the same environment on a daily basis with the same people offers you the opportunity to create strong partnerships within your group.

3. Personal service: Simultaneously, working in a practice opens the door for you to interact frequently and directly with the referring physicians who send you their patients. Building these relationships helps secure your future financial stability.

4. Greater latitude: New radiologists are frequently attracted to private practice because the path offers greater autonomy and greater schedule flexibility. In addition, compensation is often higher than in academia. According to the Association of American Medical Colleges Careers in Medicine Survey, starting salaries are approximately $285,000.

Having such close working relationships with both in-office colleagues and referring physicians will make your day-to-day work flow easier, said Brandon Selle, practice administrator for Northeast Missouri Imaging Associates. It can build your reputation as a highly-respected provider in a private practice upon which they can depend.

To read the remainder of the article at its original location: http://www.diagnosticimaging.com/practice-management/radiologists-private-practice

September 20, 2016 Posted by | Healthcare | , , , , , , , | Leave a comment

Imaging in the ‘Ivory Tower’: Academic Radiology

Published on the Aug. 25, 2016, Diagnostic Imaging website

By Whitney L. Jackson

Throughout the radiology community, there’s one thing every provider has in common. At one point in time, you all completed a residency as part of your training.

Some radiologists never left academia. Instead of opting for private practice or choosing a career in teleradiology, they’ve chosen to remain in the “Ivory Tower.” They’re providing care to your patients like every other provider, but being a radiologist in an academic setting carries its own habits, benefits, and challenges.

And, according to Vijay Rao, MD, chair of the Board of Directors for the Radiological Society of North American and radiology chair at Jefferson Medical School at Thomas Jefferson University, as well as Tejas Mehta, MD, MPH, chief of breast imaging at Harvard Medical School, it’s a job selection that they are frequently thankful for.

“I love what I do, and if I had to do it all over again, I wouldn’t change a thing,” Mehta said. “You need to be passionate about what you do, and academic radiology provides a great work-life balance at the same time.”

Still, there is much to consider if you’re contemplating an academic radiology career – or much to learn if you’ve never experienced radiology practice from this perspective.

Benefits of Academic Radiology
Alongside being able to, potentially, work side-by-side with some of radiology’s thought leaders, being an academic radiology has some upshots.

1. Subspecialty Reads: The same way your residency gives you the opportunity to concentrate on a subspecialty, opting for an academic career allows you to focus your efforts in one specific area, said Rao, who has spent her career as in head and neck imaging.

“Only academic radiology allows you the luxury of practicing only in your field rather than having to do reads of all types,” she said. “This is very meaningful in contributing to providing the highest levels of care.”

2. Staying Young: Yes, you’ll age in your career, but choosing to remain in an educational institution ensures you’ll be surrounded by the next generation of radiologists at all times. Not only are they likely to be forward-thinking as individuals, but it’s also a requirement that they keep up with the most up-to-date data and technology in providing radiological care. If you’re constantly training aspiring radiologists, your skill set won’t have time to get rusty or dated.

To read the remainder of the article at its original location: http://www.diagnosticimaging.com/practice-management/imaging-ivory-tower-academic-radiology

August 25, 2016 Posted by | Healthcare | , , , , | Leave a comment

How Glucocorticoids Can Change Fat Mass and Redistribution

Published on the Aug. 18, 2016, Rheumatology Network website

By Whitney L. J. Howell

For nearly seven decades, glucocorticoid treatment has been a common therapy for rheumatoid arthritis patients. It’s popular for other rheumatic conditions, as well, because it’s cost effective and offers strong anti-inflammatory and immunosuppressive effects. But, awareness of the negative effects is growing.

Glucocorticoids can have detrimental impacts:  osteoporosis, hyperglycemia, diabetes, cardiovascular disease and infections. Weight gain, including a red, round face, abdominal obesity with thin limbs, fat pad growth around the neck and back are also common. This weight increase, called the Cushingoid appearance, has been identified for decades and shows how glucocorticoids can impact fat metabolism. But, to date, there’s been little knowledge about how glucocorticoids can change fat mass and redistribution.

Consequently, understanding has also been minimal about the overall combination effect of rheumatoid arthritis and glucocorticoid treatments on body composition. While healthy body compositions have lower proportional body fat and higher proportional fat free mass, obesity increases the risk of high blood pressure, high cholesterol, diabetes, and cardiovascular disease.

To investigate these effects, Nicole P.C. Konijn from the Department of Rheumatology in the Amsterdam Rheumatology and Immunology Center and VU University Medical Center and colleagues conducted a study, published in Rheumatology, on the short-term effects of two high dose, step down prednisolone regimens on body composition in early rheumatoid arthritis patients. In turn, two international glucocorticoid experts from the Department of Rheumatology and Clinical Immunology at Germany’s Carité University Medicine — Frank Buttgereit and Gerd R. Burmester — analyzed the research and published a commentary in Nature Reviews.

Rheumatoid arthritis and the associated chronic inflammation affects between 0.5 percent and 1.0 percent of adults. The joint pain and stiffness associated with the condition is often attributed to a night-time rise of proteins, called cytokines, and hormones in the blood. In particular, these patients see a rise in pro-inflammatory cytokines, such as interleukin-6 and tumor necrosis factor. The same phenomenon is not seen in patients without rheumatoid arthritis.

It’s less widely known, though, that these changes also contribute to the abnormal body composition found in rheumatoid arthritis patients. Understanding this interaction is important, Buttgereit and Burmester wrote, because glucocorticoid treatment is known to facilitate fat accumulation and redistribution between the body’s trunk and limbs.

“Disease exacerbations, decreased physical activity and disuse of muscles can further reduce lean mass, leading to decreased functional capacity and serious consequences for morbidity and mortality,” Buttgereit and Burmester wrote.

Rheumatoid arthritis patients often experience rheumatoid cachexia — the replacement of lean body mass with fat mass. This condition can raise the risk for comorbidities, including diabetes and cardiovascular disease.

According to Buttgereit and Burmester, the data from Konijn’s study is particularly important because it fills in the knowledge gap, affirming there are no major changes in relative body composition that occur with some forms of glucocorticoid treatments. The researchers obtained their results by recording total body mass and using dual energy X-ray absorptiometry, a straight-forward, fast, non-invasive technique for gathering body composition measurements. They measured total fat mass, total lean mass, and trunk:peripheral fat ratio at baseline and after 26 weeks of glucocorticoid treatment.

Overall, Buttgereit and Burmester said, Konijn’s study has two major results. First, in early on-set rheumatoid arthritis patients who had never received glucocorticoid or disease modifying anti-rheumatic drug therapies, total body mass increased by 1.6 kg after 26 weeks of treatment.

The body mass index of glucocorticoid treated patients rose from 25.6 kg to 26.2 kg. That increase makes the presence of overweight and obesity at 26 weeks higher than at baseline. In fact, the 20 patients who were treated with higher cumulative glucocorticoid dose presented a 2.1 kg weight gain – more than the 1.1 kg seen in the 18 patients who received lower cumulative glucocorticoid doses. The 20 patients received a total of 2,275 mg via a combination-therapy regimen called COBRA, and their average daily dose was 12.5 mg. The 18 patients received, 1,750 mg via the same COBRA regimen, and their daily average dose was 9.6 mg.

Based on the second major result, glucocorticoid-treated patients maintained their trunk:  peripheral fat ratio and proportional distribution of total body mass and fat mass. In essence, researchers observed no fat redistribution from the body’s limbs to the trunk within the study’s timeframe. The study also didn’t point to a dose-dependent effect of COBRA versus COBRA-light body composition treatment.

These observations were surprising, however, Buttgereit and Burmester said, because it’s known that glucocorticoid treatments alter energy metabolism, induce muscle wasting and fat accumulation, and redistribute fat from body’s limbs to its trunk.

But, Buttgereit and Burmester said, Konijn’s study isn’t without its limitations. Not only was the study short at 26 weeks, but it also included a small number of patients with no control group. In addition, the difference in cumulative glucocorticoid doses between the two groups — only 525 mg after 26 weeks — could be too small to cause a dose-dependent effect.

Researchers also didn’t record any data from the time period prior to rheumatoid arthritis onset, so they can’t determine if the observed total body mass and body mass index changes truly represent a real increase or whether they can be credited to the recovery of body mass previously lost to disease and, then, regained through successful glucocorticoid treatment.

Ultimately, Buttgereit and Burmester wrote, further research should investigate the long-term effects of glucocorticoid treatment in rheumatoid arthritis and other rheumatic diseases. It should also look at how disease processes influence body composition, as well as address whether cytokine-targeting biologic drugs influence body composition.

To read the article at its original location: http://www.rheumatologynetwork.com/rheumatoid-arthritis/how-glucocorticoids-can-change-fat-mass-and-redistribution

August 21, 2016 Posted by | Healthcare | , , , , , | Leave a comment

Assessing Risk Factors for Disease Outcomes

Published Aug. 19, 2016, Rheumatology Network website

By Whitney L. Jackson

Genetic variations identified in patients with rheumatological diseases could facilitate designing clinical interventions and developing therapeutic treatments, according to a recent existing literature review.

Known as Mendelian randomization, this technique uses genetic variants, called alleles, to test whether specific risk factors are associated with or cause certain disease outcomes. This strategy could help researchers better understand existing, unmeasured confounding factors that can correlate to both dependent and independent variables, particularly environmental exposures, impacting observational studies.

The basic Mendelian randomization principle is if an environmental exposure, such a urate levels, is linked to an outcome, such as cardiovascular disease, a genetic variation will be present. Identifying these genetic variants could be helpful with rheumatological diseases.

To better understand Mendelian randomization and how it touches rheumatological conditions, researchers, led by Philp C. Robinson from the University of Queensland School of Medicine in Australia, published a systematic literature review in Nature, analyzing existing results and how they can be applied to rheumatology.

“Mendelian randomization can shed new light on cause-effect relationships in rheumatology, helping to make the case for investment in confirmatory intervention trials and to generate new hypotheses regarding pathological mechanisms and aetiology,” investigators wrote. “The technique also enables experiments to be performed that would otherwise be unethical, logistically difficult or prohibitively expensive.”

Not only can Mendelian randomization studies potentially direct clinical practice, but it can also help prioritize causal pathway interventions and help avoid unnecessary clinical trials. It can be incorporated into randomized clinical trials that test therapies for common disease risk factors, potentially explaining why targeted-intervention benefits often are lower than expected, researchers said.

Understanding the Mendelian Method

Overall, successful observational studies rely on accurate confounding factor measurements. Without that, research is hampered. However, Mendelian randomization can potentially side-step the limitation by examining single-nucleotide polymorphisms. Single-nucleotide polymorphism generally explains less than 1 percent of any observed variance, so Mendelian randomization studies typically require 10,000+ individual data sets.

Any selected genetic variants shouldn’t be associated with confounders, and they shouldn’t have pleiotropic effects. For Mendelian randomization results to be valid, investigators must satisfy three criteria:

1.      Genetic variants used should be associated with – and explain between 0.5 percent to 1.0 percent of – exposure variance to give the study adequate power.

2.      Genetic variants shouldn’t be associated with any factors that confound the exposure-outcome relationship.

3.      Genetic variants should only influence outcome through exposure and shouldn’t have pleiotropic effects.

Mendelian Randomization & Rheumatology

To date, Mendelian randomization has been applied mainly to the cause-effect relationship between urate levels and cardiometabolic traits, including coronary heart disease, high blood pressure, diabetes, obesity, body mass index, and kidney function. These studies, which also test for reverse causality, have found genetic variants associated with both hyperuricemia and gout have causal relationships with urate levels. Other studies suggest a causal role for vitamin D levels in determining responses to rheumatoid arthritis therapies and disease outcomes, as well as a causal role for high body mass index and osteoarthritis risk.

An existing literature review also revealed causal relationship results based on Mendelian randomization.

N-glycosylation of IgG in Rheumatoid Arthritis:  Researchers tested 16 variants associated with IgG-N glycosylation with 14,361 rheumatoid arthritis patients and 43,923 healthy individuals. They didn’t find a causal association of any genetic variants with rheumatoid arthritis, but a lack of data meant the genetic variants weren’t directly associated with the trait. Consequently, via Mendelian randomization, IgG-N glycosylation doesn’t cause rheumatoid arthritis, but it is a disease biomarker.

IL-1 signalling in Rheumatoid Arthritis:  Investigators used Mendelian randomization to unearth cardiovascular risks of long-term inhibition of IL-1 signalling. The study used two genetic variants affecting the gene that encodes IL-1 receptor antagonist (IL-1RA) and included 453,411 participants. Results indicated alleles associated with elevated IL-1RA expression were also linked to protection from rheumatoid arthritis and a cardiovascular disease increase.

Phosphate and Bone Mineral Density: According to Mendelian randomization, high phosphate intake affects calcium metabolism. The study, involving fewer than 200 patients, tested the genetic variant FGF23 associated with phosphate levels to identify any causal relationship with bone mineral density in children. The result was null.

Serum urate levels: Although genetic variation in five genes involved with uric acid excretion account for 3 percent to 4 percent of variance in serum urate levels, Mendelian randomization studies don’t point to a causal role for serum urate levels in hyperuricemia phenotypes, including poor kidney function, ischemic heart disease, diabetes, high blood pressure, high cholesterol, high bone mineral density, and high body mass index.

However, researchers said, reverse causality studies identify a causal effect of body fat measurements on urate levels or triglyceride levels. Among 26 serum-urate modifying genetic variants, only four revealed weak associations with blood pressure.

Additionally, a study into five urate-associated variants identified a positive serum urate level-kidney function relationship.

Rheumatoid Arthritis and Cardiovascular Disease: Rheumatoid arthritis is associated with a higher cardiovascular disease risk, and LDL cholesterol-associated genetic variants could help determine which drives the other. Mendelian randomization could also inform the paradoxical relationship between low body mass index and high mortality with rheumatoid arthritis.

Gout and Other Metabolic Diseases: Any causal relationships between gout and comorbidities are unknown. According to researchers, Mendelian randomization studies could be designed to focus on the disease’s inflammatory aspects to reveal existing links.

IL-6 Pathways and Rheumatoid Arthritis: Rheumatoid arthritis is characterized by high interleukin-6 levels with interleukin-6 inhibitors treating established cases. Mendelian randomization cardiovascular studies suggest interleukin-6 receptor inhibition is associated with cardiovascular-disease prevalence. Mendelian randomization can also address whether interleukin-6 or interleukin-6 receptor pathways contribute to cardiovascular disease development in rheumatoid arthritis patients.

Urate Levels and Neurological Disease: Research shows urate levels protect against neurodegenerative condition development, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Using Mendelian randomization to determine whether this relationship is causal could play into how aggressively providers approach reducing urate in gout.

Alcohol Intake and Rheumatoid Arthritis: Large, existing epidemiological studies suggest moderate alcohol intake reduces rheumatoid arthritis risk. Since alcohol dependence carries a substantial genetic component – approximately 30 percent heritability based on analyzed single-nucleotide polymorphism – Mendelian randomization could further investigate if alcohol intake influences rheumatoid arthritis susceptibility.

Urate Levels and Cancer: The potential urate level and cancer risk link has been well reported and is assumed to be the result of urate’s oxidative intracellular action. However, some studies find those resuls inconclusive. It’s possible the serum urate level effect on cancer risk could be location and malignancy-type dependent.

Overall, researchers said, the urate, gout, and cancer association is complex. Existing studies found higher cancer rates in patients with gout versus those without the condition. Others found no association.


Mendelian randomization isn’t a silver bullet for solving all observational-study problems, though. It’s difficult to verify the technique’s underlying assumptions aren’t being violated. And, using genetic risk scores based on multiple variants increases analysis power, but using individual variants provides for easier interpretations of biological function.

Additionally, genetic variants are mostly pulled from genome-wide association studies conducted on middle-aged and older adults. Consequently, any detected effects could arise from years of cumulative environmental exposures. As a result, investigators recommended returning to Mendelian randomization’s origins where any exposure effect on outcomes would be tested with linear or logistic regression only.

“This proposal also contains the suggestion,” researchers wrote, “that Mendelian randomization is particularly valuable in establishing null results in a large, well-powered sample sets with an established association between genetic variant and exposure but no association between genetic variant and outcomes, supporting the conclusion that little or no effect of exposure on outcome exists.”

To read the article at its original location: http://www.rheumatologynetwork.com/rheumatoid-arthritis/assessing-risk-factors-disease-outcomes

August 19, 2016 Posted by | Healthcare | , , , , | Leave a comment

Breaking Down Quality Indicators in Post-Op Rehab and PT

Published on the Aug. 15, 2016, Rheumatology Network website

By Whitney L.J. Howell

For patients with hip and knee osteoarthritis, total arthroplasty is a relatively common procedure. To date, however, no official best practice recommendations exist for post-operative rehabilitation and physical therapy services.
To clear up any confusion, Marie Westby, PT, Ph.D., from the University of British Columbia, surveyed two expert panels, including U.S. and Canadian clinicians, researchers and patients, in a three-round online Delphi survey. They offered their input on how best to proceed with maximizing and optimizing a patient’s condition post-surgery. The result was 22 best practices for total hip arthroplasty and 24 for total knee arthroplasty.
Overall, survey participants pointed to the need for supervised rehabilitation interventions provided by trained health professionals within the first two post-surgical years. However, no consensus emerged on the specifics of how these services can best be provided.
Ultimately, though, Dr. Westby said, the survey outcome is a strong step toward reducing practice variation, closing the evidence-practice gap, and improving rehabilitation service quality. Rheumatology Network spoke with Westby about the implications of her study and the impact it could have on reimbursement in the MACRA environment.
Rheumatology Network:  Why did you decide to look into best practices for total hip and knee arthroplasty?
Dr. Westby:  As a physical therapist, I provide rehabilitation services after hip and knee replacement surgery. I noticed the amount of variation in care and the different outcomes patients experienced. It started with a survey I conducted across our province in British Columbia more than 15 years ago. I was shocked by the variety of care. That’s when I decided to go back to school to formalize my research training in order to standardize or identify what the best practices are for hip and knee replacement rehabilitation.
What I saw ranged from patients having joint replacement and being discharged from the hospital with some rehabilitation or physical therapy services or they didn’t know they were supposed to receive anything or they have a really nice well-coordinated program in the community where they know what to expect. In those cases, patients start a formal rehabilitation program within a week from surgery, they’re followed for 8-to-12 weeks, and it’s a comprehensive program with excellent communication. It varies in British Columbia because we don’t have the high volume of patients that exist in the United States, so we don’t do a lot of procedures. There are fewer well-established programs. But, some places, like Vancouver does hundreds of joint replacements a year, so they have those well-established programs in place.
I was concerned that even the most basic rehabilitation wasn’t being offered to patients even in the forms of tele-rehab or single-visit follow-up care.
Rheumatology Network:   Why does identifying best practices matter?
Dr. Westby:  From the patient perspective, so much is invested in the surgery itself in terms of the cost regardless of which healthcare system they’re in. So much is put into it, and rehabilitation is a fraction of the overall cost. Patients tell us, and I’ve seen this over 25 years of practice that rehabilitation does make a difference in the overall recovery because they’ve lived with osteoarthritis or another arthritis form in their knee or hip for a decade or more. The surgery itself, while it relieves pain, restores motion, and makes improvements in basic function, still leaves a lot of problems with walking, muscle weakness and balance. Only with appropriate rehabilitation are people able to return to sports or exercise. Patients invest a lot and undertake risk to do it. I think they and the healthcare system need to invest similar amounts into their ultimate recovery. We need to optimize the outcomes. With the surgery itself, you get between 75 percent and 80 percent of the outcome of the process. The extra 20 percent to 25 percent is achieved with appropriate rehabilitation. It would be a shame to under-reach and the patient never reach their full potential.
From the provider perspective, all licensed healthcare personnel are ideally providing services and interventions that are evidence based. Best practices haven’t been identified before. People aren’t actually sure of the appropriate timing or location or type of treatment and intervention and assessment that should be done. We all want to provide the best care possible that is evidence based so that we can be effective. In many cases, that will allow us to be more efficient and save dollars. That connection between best practices and cost savings has been established in other areas. The literature, though, that we have to work with in hip and knee replacements is weak. It would be nice to know that we’re providing effective care at a reduced cost.
Rheumatology Network:  What are the most important parts of your results? What are their impacts?
Dr. Westby:  The most important thing is the strong support for the need for structured and supervised rehabilitation by all of the experts in the survey panel. The panel, as a whole, agreed it’s necessary, but there was no agreement on timing or location for where the services should be rendered. It helps patients prepare for the experienced if they know what’s in place after surgery. They’ll know what to look for.
The work I’ve gone on to do deals with the minimum standards of care based on quality indicators. Patients are better able to monitor their own care and can prepared to be more engaged. They can look for providers who offer similar levels of care so they don’t have to be as concerned about the specific provider from whom they receive care. Supervision can be through the telephone or video, or it can be a follow-up visit one time to the clinic.
There are different ways to do it. It doesn’t always have to be once or twice a week in the office. Patients just need to know that there’s someone there to answer their questions in a timely manner if they have any because there’s very little contact with the surgeons after the procedure is complete. Maybe there’s a 3-to-6 week visit and a 6-to-12 month visit. Really, it’s the physical therapy and rehabilitation provides to offer the interim educational support and answers to questions in the immediate post-operative period.
Rheumatology Network:   Was there anything unexpected in your findings? Anything that could present a challenge?
Dr. Westby:  Something that really came out – that I’m glad to see – is that the literature is addressing the contextual issues that impact rehabilitation care and outcomes. Some of those issues have to do with the patients themselves and their own general health, anxiety, depression and the kind of medical coverage they have. I found it interesting that regardless of what role the survey panelist played – research, clinical, surgeon or physical therapist – they really recognized how important it is to consider the personal and external factors when looking into what kind of rehabilitation services or outcomes you can expect. And, the larger registries are starting to collect this information, as well.
Based on an analysis of survey panelists responses compared to patient response. It was evident that there’s variability between the experts about what they thought was important about the right timing and appropriate provider for rehabilitation services, as well as what the appropriate setting would be. Even though they came to a consensus about the need for supervised services, their views differed in other aspets of joint replacements.
I was surprised about the timing. They really couldn’t come to an agreement about whether rehabilitation for knee and hip replacement should start right away after the hospital discharge or to wait several weeks. There was a lack of consensus around the setting. They couldn’t come to an agreement, and that’s actually a good thing. It shows that rehabilitation services can be provided in a variety of settings and one isn’t necessarily better than the other.
One of the things I’m working on with colleagues is trying to define the minimal dosage in terms of rehabilitation. The panel didn’t come to an agreement on how many days a week or for how many hours a session rehab should go one. Nor did they decide the intensity. And, that’s how payments are determined. They’re often made based on the number of visits. Many extend out to 90 days post-discharge, but it’s never been established that 90 days is the ultimate rehabilitation dosage for hip and knee replacement. It’s ranged anywhere from less than 3-to-4 weeks to up to 20-to-24 weeks. It’s surprising and frustrating because those numbers and dosages are what payments for services are based on.
Rheumatology Network:   How does this research fit in with MACRA and changing reimbursement policies?
Dr. Westby:  I think it’s going to be the follow-up on the most recent work with quality indicators that’s going to make the difference. Expert opinion is considered low-level evidence. Now, we can take that and move forward to identify quality indicators that are true measurements that will reflect the standard of care. They will be used to provide care within the bundled payment approach in terms of letting providers know what they should monitor and report on.
Rheumatology Network:   How can your work be used to promote better and improved outcomes?
Dr. Westby:  The project I’m working on now is to develop two separate tool kits. The first is for patients and family members to help them understand the quality indicators so they now have a minimum standard of care that they know they should receive. It helps them understand how to use the indicators to engage in their own care and discuss it with providers. And, in some circumstances, it might help them identify a provider to go to. If they have the choice within the community to see one private practice or another, patients can look at measurement indicators and see what the practice is reporting on. What do they make available on their website? How can the patient use that information to make an informed decision?
The other tool kit is for the healthcare professional, and it develops tools that are ideal for therapy and rehabilitation purposes. It can be used at the point of care for real-time decision making. Right now, most quality indicators come from data collected from electronic medical records or registries or questionnaires conducted after the fact. Data from questionnaires doesn’t help because it’s not collected in real time. It’s responsive, and the patient can’t benefit from it.
In Canada, we don’t have pay-for-performance, but it might be coming. Regardless, private practices can monitor their data to help them fill in the gaps when they aren’t doing well in certain areas. They can take those measurements and do a quality improvement programs, address the problems, and find some areas where they can create better outcomes. Many multi-site clinics can find the ones that aren’t performing as well as the others. Maybe they aren’t seeing as many patients, and they could identify ways to increase patient volume or reduce costs. It can be used for marketing purposes. If they’re willing to look at where they have gaps and possibly aren’t performing well, they can make improvements.
Rheumatology Network:   What do you see as the next steps?
Dr. Westby:  I’m really focusing on physical therapy and encouraging providers to get involved in the whole process in both the United States and Canada. If they don’t have a say in which measures are included or acceptable for the quality reporting used to support bundled care, then the ones that are selected as measures, they might find aren’t applicable to them or they’re just not feasible Or, perhaps they don’t really guide practice. And, the ultimate downside is that this affects their remuneration. Providers really need to have a say in what’s chosen. They need to participate in forums and meetings where people are selecting which measures to use.
To read the Q&A at its original location: http://www.rheumatologynetwork.com/news/breaking-down-quality-indicators-post-op-rehab-and-pt

August 18, 2016 Posted by | Healthcare | , , , , | Leave a comment

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